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In an embodiment, ciprofloxacin english online the 7,9-substituted tetracycline compound is 7,9-substituted tetracycline (e.g., wherein R 4 is NR 4'R 4"; R 4' and R 4" are methyl, R 5 is hydrogen and X is CR 6R 6', wherein R 6 is methyl and R 6' is hydroxy); 7,9-substituted doxycycline (e.g., wherein R 4 is NR 4'R 4"; R 4' and R 4" are methyl, R 5 is hydroxyl and X is CR 6R 6', wherein R 6 is methyl and R 6' is hydrogen); or 7, 9- substituted sancycline (wherein R 4 is NR 4'R 4"; R 4' and R 4" are methyl; R 5 is hydrogen and X is CR 6R 6' wherein R 6 and R 6' are hydrogen atoms. Examples of sancycline compounds with this R 7 substituent include 7-(4' -aminomethylphenyl) 4-dedimethylamino sancycline. If hypotension occurs (systolic blood pressure ≤ 100 mmHg) a daily maintenance dose of 5 mg may be given with temporary reductions to 2.5 mg if needed.

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